is an "end of line" legacy MIDI controller that is on modern macOS versions . While it was a popular, budget-friendly choice for synth-style playing, using its direct USB connection on current Macs requires unofficial workarounds. Mac Compatibility & Driver Status
Because this is a long-form article, standard scannability rules are bypassed to provide a natural, publication-ready format.
You will need a simple, class-compliant USB-to-MIDI cable adapter (such as the iConnectivity mio, Roland UM-ONE, or a budget alternative).
If you need help setting up your specific recording software, let me know you are using, your macOS version , and what hardware you currently have available to connect the keyboard. Share public link
The M-Audio Radium 49 Go to product viewer dialog for this item.
Some early Radium units were designed to be "class-compliant" (meaning they don't need a custom driver). If your Mac does not recognize the USB connection at all, it is likely the legacy firmware is not communicating with modern macOS. Connect the keyboard via USB to your Mac. Open > MIDI Studio .
If you are dedicated to keeping an older Mac studio machine running, or you are running a vintage Mac OS X environment, you can use the direct USB connection with official legacy drivers. Driver Compatibility Matrix
M-Audio Radium 49 Driver for Mac: Complete Setup Guide (2026 Updated)
is an older USB device that requires more power than some modern, low-power USB-C ports can provide.
However, fast forward to 2025, and a common search query echoes through recording forums: . If you have pulled this controller out of storage or bought one used for its rugged build, you have likely hit a wall. Mac’s operating system has evolved from PowerPC to Intel, and now to Apple Silicon (M1/M2/M3), dropping support for older peripheral protocols along the way.
Because the direct USB connection is blocked by missing driver software, you must use one of two hardware-based workarounds to route the MIDI data into your Mac.
However, you can make it work. This article explains the methods to revive your Radium 49 on modern Apple Silicon and Intel Macs. Method 1: The USB-to-MIDI Interface Route (Recommended)